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# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "DrDimont" in publications use:'
type: software
license: MIT
title: 'DrDimont: Drug Response Prediction from Differential Multi-Omics Networks'
version: 0.1.6
doi: 10.1093/bioinformatics/btac477
identifiers:
- type: doi
  value: 10.32614/CRAN.package.DrDimont
abstract: While it has been well established that drugs affect and help patients differently,
  personalized drug response predictions remain challenging. Solutions based on single
  omics measurements have been proposed, and networks provide means to incorporate
  molecular interactions into reasoning. However, how to integrate the wealth of information
  contained in multiple omics layers still poses a complex problem. We present a novel
  network analysis pipeline, DrDimont, Drug response prediction from Differential
  analysis of multi-omics networks. It allows for comparative conclusions between
  two conditions and translates them into differential drug response predictions.
  DrDimont focuses on molecular interactions. It establishes condition-specific networks
  from correlation within an omics layer that are then reduced and combined into heterogeneous,
  multi-omics molecular networks. A novel semi-local, path-based integration step
  ensures integrative conclusions. Differential predictions are derived from comparing
  the condition-specific integrated networks. DrDimont's predictions are explainable,
  i.e., molecular differences that are the source of high differential drug scores
  can be retrieved. Our proposed pipeline leverages multi-omics data for differential
  predictions, e.g. on drug response, and includes prior information on interactions.
  The case study presented in the vignette uses data published by Krug (2020) <https://doi.org/10.1016/j.cell.2020.10.036>.
  The package license applies only to the software and explicitly not to the included
  data.
authors:
- family-names: Baum
  given-names: Katharina
  email: katharina.baum@fu-berlin.de
  orcid: https://orcid.org/0000-0001-7256-0566
- family-names: Hiort
  given-names: Pauline
  email: pauline.hiort@hpi.de
  orcid: https://orcid.org/0000-0002-3530-7358
- family-names: Hugo
  given-names: Julian
  orcid: https://orcid.org/0000-0003-3355-1071
- family-names: Kashyap
  given-names: Spoorthi
  orcid: https://orcid.org/0000-0002-5474-8183
- family-names: Müller
  given-names: Nataniel
  orcid: https://orcid.org/0000-0002-0275-3992
- family-names: Zeinert
  given-names: Justus
  orcid: https://orcid.org/0000-0003-3918-0507
preferred-citation:
  type: article
  title: 'DrDimont: Explainable drug response prediction from differential analysis
    of multi-omics networks'
  authors:
  - name: Hiort
  - name: Pauline
  - name: Hugo
  - name: Julian
  - name: Zeinert
  - name: Justus
  - name: M\"uller
  - name: Nataniel
  - name: Kashyap
  - name: Spoorthi
  - name: Rajapakse
  - family-names: C.
    given-names: Jagath
  - name: Azuaje
  - name: Francisco
  - name: Renard
  - family-names: Y.
    given-names: Bernhard
  - name: Baum
  - name: Katharina
  journal: Bioinformatics
  year: '2022'
  volume: '38'
  issue: Supplement_2
  doi: 10.1093/bioinformatics/btac477
  url: https://doi.org/10.1093/bioinformatics/btac477
  start: ii113–ii119
repository: https://cranhaven.r-universe.dev
commit: 35e6dcfe5782d42235cfcc290cec21a0a19e1337
date-released: '2026-05-16'
contact:
- family-names: Baum
  given-names: Katharina
  email: katharina.baum@fu-berlin.de
  orcid: https://orcid.org/0000-0001-7256-0566